Study confirms why we need female mice in neuroscience ...
Mar 8, 2023 · Researchers found that female mice, despite ongoing hormonal fluctuations, exhibit exploratory behavior that is more stable than that of their male peers, countering the belief that the hormone cycle in females causes behavioral variation that could throw off results.
The Case for Female Mice in Neuroscience Research
Mar 7, 2023 · Historically, researchers have favored male mice over female mice in experiments, in part due to concern that the hormone cycle in females causes behavioral variation that could throw off results. Findings reveal female mice have …
The Stage of the Estrus Cycle Is Critical for Interpretation ...
The mouse estrus cycle occurs over 2–8 days as indicated by the histogram representing the length of estrus cycle for n = 41 female mice (E) and is represented by four distinct stages: proestrus (A), estrus (B), diestrus (C) and metestrus (D). Each stage of the cycle is distinguished using vaginal cytology and identification of specific cell ...
Female mice behave well - Nature Neuroscience
Apr 5, 2023 · To examine this question, Levy et al. used Mo-Seq, a machine learning algorithm that enables unbiased, high-dimensional analysis of mouse behavior, to profile adult C57BL/6J female mice...
Why we need female mice in drug trials :: Understanding ...
Mar 8, 2019 · Female mice are generally tested at each of the four stages of oestrus to generate reliable data. There is also concern that the use of males and females in a same study could reduce statistical power because of a greater spread …
Female mice liberated for inclusion in neuroscience and ...
The underrepresentation of female mice in neuroscience and biomedical research is based on the assumption that females are intrinsically more variable than males and must be tested at each of four stages of the estrous cycle to generate reliable data.
Memory capacity and prioritization in female mice - Nature
Aug 28, 2023 · Here we report a new serial novel object recognition task designed to measure memory capacity and prioritization, which we test and validate using female mice.
The influence of sex difference on behavior and adult ...
Oct 12, 2023 · This study sets out to evaluate whether a sex difference does exist in mouse behavior, and whether female mice featured higher variability.
Hormones Don’t Affect Behavior of Female Mice, Study Finds ...
Mar 7, 2023 · A new study finds male mice more unpredictable than females, challenging century-old assumptions used to exclude females from research because of their hormones.
The case for female mice in neuroscience research
Mar 7, 2023 · The study results, published March 7 in Current Biology, reveal that female mice, despite ongoing hormonal fluctuations, exhibit exploratory behavior that is more stable than that of their male...