Yellow fever vaccine is highly effective with a single dose, but vaccine supply is limited. The minimum dose requirements for seroconversion remain unknown. In this double-blind, randomized ...

Many inhalers that are vital for patients with asthma or COPD are associated with societal harms that can worsen the very diseases the products are designed to treat. How can this dilemma be resolved?

Dr. Brian Y. Chang (Medicine): A 62-year-old man was admitted to this hospital because of abdominal pain. Two years before the current presentation, postprandial abdominal pain developed.

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

The WHO advises using fractional doses of the 17D yellow fever vaccine when outbreaks occur during vaccine shortages, but evidence on the immunogenicity of these lower doses is limited. New ...

Supported by Swim Across America, the Simon and Eve Colin Foundation, the Dalton Family Foundation, the American Association for Cancer Research–Stand Up To Cancer Colorectal Cancer Dream Team ...

How combination therapy with acalabrutinib, a second-generation Bruton’s tyrosine kinase inhibitor, compares with chemoimmunotherapy in patients with previously untreated CLL has been unclear.

A UNIQUE feature of military medicine is the opportunity it provides for periodic physical examination of young adults. These examinations offer an unparalleled situation for the diagnosis of ...

Dr. Carlos A. Portales Castillo (Medicine): A 30-year-old woman was admitted to this hospital because of headache and dysesthesia. The patient had been in her usual state of good health until 8 ...

Familial HLH is a success story in modern medicine. Initially a disease that was largely unknown and fatal, it is now understood on a molecular level and is curable. Moreover, HLH is an archetype ...

We describe two patients in whom malignant monoclonal T-cell lymphoproliferation developed after administration of chimeric antigen receptor (CAR) T-cell therapy with ciltacabtagene autoleucel ...