The San Francisco 49ers defeated the New Orleans Saints on Sunday. Here's who had the best and worst days, according to Pro Football Focus.

The San Francisco 49ers started Mac Jones at quarterback, and defensive end Nick Bosa was impressed by his swagger on Sunday.

Florida is considering becoming the first state in decades to waive all school vaccine requirements. Louisiana's public ...

San Francisco 49ers head coach Kyle Shanahan addressed his team after their Week 2 win over the New Orleans Saints at Caesars Superdome.

Senator Bill Cassidy was the swing vote to confirm RFK Jr. as the nation's health secretary despite reservations over Kennedy's vaccine skepticism.

As the 49ers start gearing up for an NFC West battle of unbeatens against the Arizona Cardinals (2-0), San Francisco has a number of performances to celebrate coming out of its win over the Saints.

Injuries are the story of the game for the 49ers entering Sunday. Quarterback Mac Jones will start with Brock Purdy out, and wide receiver Jauan Jennings and left tackle Trent Williams are both ...

For 13th time in history, a lottery jackpot reached $1 billion. Winning numbers for Saturday, Sept. 6, 2025, Powerball. Who won biggest prizes ever?

San Francisco 49ers fullback Kyle Juszczyk has been ruled out for the rest of the team's battle with the New Orleans Saints ...

Even on a limited snap count, edge rusher Micah Parsons showed why he might be the difference this season for the Green Bay ...

The San Francisco 49ers may have lost starting offensive lineman Ben Bartch early in their Week 2 matchup against the New Orleans Saints.

It wasn't pretty, but the San Francisco 49ers will take a win over the Saints in New Orleans. We have the takeaways.